July 14, 2014
The discovery 30 years ago of soccer-ball-shaped carbon molecules called buckyballs helped to spur an explosion of nanotechnology research. Now, there appears to be a new ball on the pitch.
Researchers from Brown University, Shanxi University and Tsinghua University in China have shown that a cluster of 40 boron atoms forms a hollow molecular cage similar to a carbon buckyball. It’s the first experimental evidence that a boron cage structure – previously only a matter of speculation – does indeed exist.
“This is the first time that a boron cage has been observed experimentally,” said Lai-Sheng Wang, a professor of chemistry at Brown who led the team that made the discovery. “As a chemist, finding new molecules and structures is always exciting. The fact that boron has the capacity to form this kind of structure is very interesting.”
Wang and his colleagues describe the molecule, which they’ve dubbed borospherene, in the journal Nature Chemistry.
Carbon buckyballs are made of 60 carbon atoms arranged in pentagons and hexagons to form a sphere – like a soccer ball. Their discovery in 1985 was soon followed by discoveries of other hollow carbon structures including carbon nanotubes. Another famous carbon nanomaterial – a one-atom-thick sheet called graphene – followed shortly after.
After buckyballs, scientists wondered if other elements might form these odd hollow structures. One candidate was boron, carbon’s neighbor on the periodic table. But because boron has one less electron than carbon, it can’t form the same 60-atom structure found in the buckyball. The missing electrons would cause the cluster to collapse on itself. If a boron cage existed, it would have to have a different number of atoms.
Wang and his research group have been studying boron chemistry for years. In a paper published earlier this year, Wang and his colleagues showed that clusters of 36 boron atoms form one-atom-thick disks, which might be stitched together to form an analog to graphene, dubbed borophene. Wang’s preliminary work suggested that there was also something special about boron clusters with 40 atoms. They seemed to be abnormally stable compared to other boron clusters. Figuring out what that 40-atom cluster actually looks like required a combination of experimental work and modeling using high-powered supercomputers.
On the computer, Wang’s colleagues modeled over 10,000 possible arrangements of 40 boron atoms bonded to each other. The computer simulations estimate not only the shapes of the structures, but also estimate the electron binding energy for each structure – a measure of how tightly a molecule holds its electrons. The spectrum of binding energies serves as a unique fingerprint of each potential structure.
The next step is to test the actual binding energies of boron clusters in the lab to see if they match any of the theoretical structures generated by the computer. To do that, Wang and his colleagues used a technique called photoelectron spectroscopy.
Chunks of bulk boron are zapped with a laser to create vapor of boron atoms. A jet of helium then freezes the vapor into tiny clusters of atoms. The clusters of 40 atoms were isolated by weight then zapped with a second laser, which knocks an electron out of the cluster. The ejected electron flies down a long tube Wang calls his “electron racetrack.” The speed at which the electrons fly down the racetrack is used to determine the cluster’s electron binding energy spectrum – its structural fingerprint.
The experiments showed that 40-atom-clusters form two structures with distinct binding spectra. Those spectra turned out to be a dead-on match with the spectra for two structures generated by the computer models. One was a semi-flat molecule and the other was the buckyball-like spherical cage.
“The experimental sighting of a binding spectrum that matched our models was of paramount importance,” Wang said. “The experiment gives us these very specific signatures, and those signatures fit our models.”
The borospherene molecule isn’t quite as spherical as its carbon cousin. Rather than a series of five- and six-membered rings formed by carbon, borospherene consists of 48 triangles, four seven-sided rings and two six-membered rings. Several atoms stick out a bit from the others, making the surface of borospherene somewhat less smooth than a buckyball.
As for possible uses for borospherene, it’s a little too early to tell, Wang says. One possibility, he points out, could be hydrogen storage. Because of the electron deficiency of boron, borospherene would likely bond well with hydrogen. So tiny boron cages could serve as safe houses for hydrogen molecules.
But for now, Wang is enjoying the discovery.
“For us, just to be the first to have observed this, that’s a pretty big deal,” Wang said. “Of course if it turns out to be useful that would be great, but we don’t know yet. Hopefully this initial finding will stimulate further interest in boron clusters and new ideas to synthesize them in bulk quantities.”
The theoretical modeling was done with a group led by Prof. Si-Dian Li from Shanxi University and a group led by Prof. Jun Li from Tsinghua University. The work was supported by the U.S. National Science Foundation (CHE-1263745) and the National Natural Science Foundation of China.’
July 11, 2014
Why does a relentless stream of subjective experiences normally fill your mind? Maybe that’s just one of those mysteries that will always elude us.
Yet, research from Northwestern University suggests that consciousness lies well within the realm of scientific inquiry — as impossible as that may currently seem. Although scientists have yet to agree on an objective measure to index consciousness, progress has been made with this agenda in several labs around the world.
“The debate about the neural basis of consciousness rages because there is no widely accepted theory about what happens in the brain to make consciousness possible,” said Ken Paller, professor of psychology in the Weinberg College of Arts and Sciences and director of the Cognitive Neuroscience Program at Northwestern.
“Scientists and others acknowledge that damage to the brain can lead to systematic changes in consciousness. Yet, we don’t know exactly what differentiates brain activity associated with conscious experience from brain activity that is instead associated with mental activity that remains unconscious,” he said.
In a new article, Paller and Satoru Suzuki, also professor of psychology at Northwestern, point out flawed assumptions about consciousness to suggest that a wide range of scientific perspectives can offer useful clues about consciousness.
“It’s normal to think that if you attentively inspect something you must be aware of it and that analyzing it to a high level would necessitate consciousness,” Suzuki noted. “Results from experiments on perception belie these assumptions.
“Likewise, it feels like we can freely decide at a precise moment, when actually the process of deciding begins earlier, via neurocognitive processing that does not enter awareness,” he said.
The authors write that unconscious processing can influence our conscious decisions in ways we never suspect.
If these and other similar assumptions are incorrect, the researchers state in their article, then mistaken reasoning might be behind arguments for taking the science of consciousness off the table.
“Neuroscientists sometimes argue that we must focus on understanding other aspects of brain function, because consciousness is never going to be understood,” Paller said. “On the other hand, many neuroscientists are actively engaged in probing the neural basis of consciousness, and, in many ways, this is less of a taboo area of research than it used to be.”
Experimental evidence has supported some theories about consciousness that appeal to specific types of neural communication, which can be described in neural terms or more abstractly in computational terms. Further theoretical advances can be expected if specific measures of neural activity can be brought to bear on these ideas.
Paller and Suzuki both conduct research that touches on consciousness. Suzuki studies perception, and Paller studies memory. They said it was important for them to write the article to counter the view that it is hopeless to ever make progress through scientific research on this topic.
They outlined recent advances that provide reason to be optimistic about future scientific inquiries into consciousness and about the benefits that this knowledge could bring for society.
“For example, continuing research on the brain basis of consciousness could inform our concerns about human rights, help us explain and treat diseases that impinge on consciousness, and help us perpetuate environments and technologies that optimally contribute to the well being of individuals and of our society,” the authors wrote.
They conclude that research on human consciousness belongs within the purview of science, despite philosophical or religious arguments to the contrary.
Their paper, “The Source of Consciousness,” has been published online in the journal Trends in Cognitive Sciences.
July 11, 2014
Researchers from Salk Institute for Biological Studies, BGI, and other institutes for the first time evaluated the safety and reliability of the existing targeted gene correction technologies, and successfully developed a new method, TALEN-HDAdV, which could significantly increased gene-correction efficiency in human induced pluripotent stem cell (hiPSC). This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene therapy.
The combination of stem cells and targeted genome editing technology provides a powerful tool to model human diseases and develop potential cell replacement therapy. Although the utility of genome editing has been extensively documented, but the impact of these technologies on mutational load at the whole-genome level remains unclear.
In the study, researchers performed whole-genome sequencing to evaluate the mutational load at single-base resolution in individual gene-corrected hiPSC clones in three different disease models, including Hutchinson-Gilford progeria syndrome (HGPS), sickle cell disease (SCD), and Parkinson’s disease (PD).
They evaluated the efficiencies of gene-targeting and gene-correction at the haemoglobin gene HBB locus with TALEN, HDAdV, CRISPR/CAS9 nuclease, and found the TALENs, HDAdVs and CRISPR/CAS9 mediated gene-correction methods have a similar efficiency at the gene HBB locus. In addition, the results of deep whole-genome sequencing indicated that TALEN and HDAdV could keep the patient’s genome integrated at a maximum level, proving the safety and reliability of these methods.
Through integrating the advantages of TALEN- and HDAdV-mediated genome editing, researchers developed a new TALEN-HDAdV hybrid vector (talHDAdV), which can significantly increase the gene-correction efficiency in hiPSCs. Almost all the genetic mutations at the gene HBB locus can be detected by telHDAdV, which allows this new developed technology can be applied into the gene repair of different kinds of hemoglobin diseases such as SCD and Thalassemia.
June 6, 2014
New research from Case Western Reserve University found that compassion can produce counterintuitive results, challenging prevailing views of empathy’s effects on moral judgment.
To understand how humans make moral choices, researchers asked subjects to respond to a variety of moral dilemmas, for instance: Whether to stay and defend a mortally wounded soldier until he dies or shoot him to protect him from enemy torture and enable you and five other soldiers to escape unharmed.
Leading research has said people make choices based on a struggle within their brains between thoughtful reason and automatic passion.
“But this simple reason versus passion model fails to capture that there’s a refined way of thinking with emotions, closely related to empathy and compassion,” said Anthony Jack, Director of Research at the Inamori International Center for Ethics and Excellence, associate professor of cognitive science, psychology and philosophy at Case Western Reserve and lead author of the new research.
Co-authors are Philip Robbins, of the department of philosophy at the University of Missouri, Jared P. Friedman, who just graduated with a BA in cognitive science and philosophy from Case Western Reserve, and Chris D. Meyers, of the department of philosophy at the University of Southern Mississippi. Their study is published in the journal Advances in Experimental Philosophy of Mind at: http://www.bloomsbury.com/us/advances-in-experimental-philosophy-of-mind-9781472507334/.
The researchers agree that there are two networks in the brain that fight to guide our moral decisions, but say that leading work, by Joshua Greene at Harvard University, mischaracterizes the networks involved and how they operate.
A new model
“There’s a tension between cold hard reasoning – what’s called analytic reasoning – and another type of reasoning important to emotions, self-regulation and social insight,” Jack explained. “The second type of reasoning isn’t characterized by being caught up in reflexive and primitive emotions, as Greene suggests. It’s critically important to understanding and appreciating the experiential point of view of others.”
Using functional magnetic resonance imagers (fMRI), Jack has found that the human brain has an analytic network and an empathetic network that tend to suppress one another.
For example, in a healthy brain, physics problems activate the analytic network and deactivate the empathetic. Meanwhile, videos or stories that put a subject in the shoes of another activate the empathetic network and deactivate the analytic.
In these studies, students from Case Western Reserve and groups of adults recruited through Amazon Mechanical Turk responded to a series of questions about themselves and their views. They were then asked to make choices about a series of moral conundrums.
Among the conundrums were questions involving euthanasia. The respondents clearly made different choices between actions taken for a suffering dog versus a suffering person.
“For humans, we privilege their autonomy or life spirit over their basic emotions, such as how much pain they’re in. In contrast, our view of non-human animals tends to be more reductive – we see them as little more than their emotions” Jack said.
“Even though people talk about euthanasia with animals as the humane thing to do, people who are more empathetic have the greatest opposition to euthanasia involving a human,” he said.
Subjects were presented scenarios that included passive euthanasia, such as halting medical intervention, and active euthanasia, such as assisting in the subject’s death.
“More compassionate people didn’t think euthanasia was appropriate for humans, even when we told them the person would be in pain for the rest of his or her life,” Jack said. “That is surprising, because the way we measure compassion is to assess how much people are concerned by the suffering of others.”
Here again, the researchers argue, Greene’s model falls short. According to Greene, those who oppose utilitarian thinking (e.g., euthanasia), should have higher levels of reflexive, primitive, raw emotion Instead, the researchers found that those who were more susceptible to personal distress were actually more likely to support euthanasia.
Opposition to utilitarian thinking was predicted specifically by compassion, not by measures of primitive or reflexive emotion. “Our culture often paints empathy as weakness,” Jack said, “Greene’s model plays into that view, suggesting that those who don’t like utilitarian thinking are intellectually weak and ruled by primitive passions. But these views are fundamentally misleading. Compassion is actually linked to stronger emotion regulation abilities. Decades of research shows that we have to overcome our reflexive feelings of aversion and distress to be ready and willing to help others.”
The researchers found that people judged to be more compassionate and empathetic by their peers – for instance better listeners – tended to oppose utilitarian choices such as sacrificing one to save the many or euthanasia.
The findings suggest that more compassionate people have more of a sense of the sanctity of human life. “The idea that life is sacred may be hard for the reductive, analytic mind to grasp, but it is hardly a primitive or reflexive sentiment” Jack said.
That’s not to say that, given more information, the compassionate will continue to oppose euthanasia. The conundrums were limited in an important way: the test subjects knew nothing about the wishes of the person suffering.
The researchers are continuing their studies. They expect to see a different relationship between compassion and moral judgments about euthanasia when more is understood about the person who is suffering, in particular when continued suffering undermines that person’s life narrative.
May 28, 2014
Spontaneous thoughts, intuitions, dreams and quick impressions. We all have these seemingly random thoughts popping into our minds on a daily basis. The question is what do we make of these unplanned, spur-of-the-moment thoughts? Do we view them as coincidental wanderings of a restless mind, or as revealing meaningful insight into ourselves?
A research team from Carnegie Mellon University and Harvard Business School set out to determine how people perceive their own spontaneous thoughts and if those thoughts or intuitions have any influence over judgment. Published in the “Journal of Experimental Psychology: General,” their research found that spontaneous thoughts are perceived to provide potent self-insight and can influence judgment and decisions more than similar, more deliberate kinds of thinking – even on important topics such as commitment to current romantic partners.
“We are aware of the output of spontaneous thoughts, but lack insight into the reasons why and processes by which they occurred. Rather than dismiss these seemingly random thoughts as meaningless, our research found that people believe, precisely because they are not controlled, that spontaneous thoughts reveal more meaningful insight into their own mind – their beliefs, attitudes, and preferences – than similar deliberate thoughts. As a consequence, spontaneous thoughts can have a more potent influence on judgment,” said Carey K. Morewedge, lead author and associate professor of marketing in the Tepper School of Business with an additional appointment in the Dietrich College’s Department of Social and Decision Sciences. “People often believe their intuitions, dreams and or random thoughts reveal more insight than the result of more effortful thinking and reasoning. This research helps to explain these curious beliefs. ”
For the study, Morewedge, CMU’s Colleen E. Giblin and Harvard University’s Michael I. Norton ran five studies. The first three were designed to test the hypothesis that the more spontaneous a thought is, the more it is believed to provide meaningful self-insight. Participants rated the extent to which different thought categories are spontaneous or controlled and the extent to which each provides self-insight; they recalled either a pleasant or unpleasant childhood event and evaluated the degree that the recollection would provide meaningful self-insight if it happened spontaneously or deliberately; and they generated thoughts about four strangers through a deliberative or spontaneous process and rated how much those thoughts provided them with valuable self-insight.
The results suggest that when people evaluate a particular thought, they not only consider its content, they are also influenced by their more general beliefs about different thought processes. Thoughts with the same content are judged to be more meaningful if they occurred through a spontaneous, uncontrolled process rather than a deliberate, controlled process. The effect was found across various kinds of thought and thought content, including thoughts about other people. This means that the content of spontaneous thought need not be entirely about the self in order for people to feel like they’ve gleaned meaningful self-insight.
The last two experiments extended the investigation to determine if the greater insight attributed to spontaneous thoughts leads them to have a greater impact on judgment. The researchers tested this first by having participants think about a love interest other than their present or most recent significant other spontaneously or deliberately, report the self-insight that the thought provided and then indicate their attraction toward that person. They found that those who spontaneously generated a thought of a love interest believed that thought revealed more self-insight and perceived their attraction to be stronger than the participants who identified a love interest with deliberate thinking.
Finally, to determine whether this greater influence would extend to both positive and negative spontaneous thoughts, participants recalled a positive or negative experience related to their current or most recent romantic relationship. Participants reported the extent to which the spontaneous and deliberate recollection of that memory would provide them with meaningful self-insight and increase or decrease the likelihood that they would end the relationship. The results showed that participants believed the recollection of a positive or negative experience with their current romantic partner would reveal more self-insight and have a greater influence on their commitment to that relationship if it was recalled spontaneously rather than deliberately.
“The perception that a thought popped into mind out of nowhere can lead people to overvalue their own insights. When considering a thought that came to mind spontaneously, it may be useful to ask yourself the following question: had the same thought come to mind after careful deliberation, would it seem just as meaningful? If you realize that your interpretation of a particular thought depends on whether it came to mind spontaneously, that’s an indication that your beliefs about these different kinds of thoughts might be affecting your judgment,” said Giblin, a doctoral student in CMU’s Tepper School of Business.
Carnegie Mellon University and Harvard Business School funded this research.
May 20, 2014
A cluster of closely timed earthquakes over 100 years in the 17th and 18th centuries released as much accumulated stress on San Francisco Bay Area’s major faults as the Great 1906 San Francisco earthquake, suggesting two possible scenarios for the next “Big One” for the region, according to new research published by the Bulletin of the Seismological Society of America (BSSA).
“The plates are moving,” said David Schwartz, a geologist with the U.S. Geological Survey and co-author of the study. “The stress is re-accumulating, and all of these faults have to catch up. How are they going to catch up?”
The San Francisco Bay Region (SFBR) is considered within the boundary between the Pacific and North American plates. Energy released during its earthquake cycle occurs along the region’s principal faults: the San Andreas, San Gregorio, Calaveras, Hayward-Rodgers Creek, Greenville, and Concord-Green Valley faults.
“The 1906 quake happened when there were fewer people, and the area was much less developed,” said Schwartz. “The earthquake had the beneficial effect of releasing the plate boundary stress and relaxing the crust, ushering in a period of low level earthquake activity.”
The earthquake cycle reflects the accumulation of stress, its release as slip on a fault or a set of faults, and its re-accumulation and re-release. The San Francisco Bay Area has not experienced a full earthquake cycle since its been occupied by people who have reported earthquake activity, either through written records or instrumentation. Founded in 1776, the Mission Dolores and the Presidio in San Francisco kept records of felt earthquakes and earthquake damage, marking the starting point for the historic earthquake record for the region.
“We are looking back at the past to get a more reasonable view of what’s going to happen decades down the road,” said Schwartz. “The only way to get a long history is to do these paleoseismic studies, which can help construct the rupture histories of the faults and the region. We are trying to see what went on and understand the uncertainties for the Bay Area.”
Schwartz and colleagues excavated trenches across faults, observing past surface ruptures from the most recent earthquakes on the major faults in the area. Radiocarbon dating of detrital charcoal and the presence of non-native pollen established the dates of paleoearthquakes, expanding the span of information of large events back to 1600.
The trenching studies suggest that between 1690 and the founding of the Mission Dolores and Presidio in 1776, a cluster of earthquakes ranging from magnitude 6.6 to 7.8 occurred on the Hayward fault (north and south segments), San Andreas fault (North Coast and San Juan Bautista segments), northern Calaveras fault, Rodgers Creek fault, and San Gregorio fault. There are no paleoearthquake data for the Greenville fault or northern extension of the Concord-Green Valley fault during this time interval.
“What the cluster of earthquakes did in our calculations was to release an amount of energy somewhat comparable to the amount released in the crust by the 1906 quake,” said Schwartz.
As stress on the region accumulates, the authors see at least two modes of energy release – one is a great earthquake and other is a cluster of large earthquakes. The probability for how the system will rupture is spread out over all faults in the region, making a cluster of large earthquakes more likely than a single great earthquake.
“Everybody is still thinking about a repeat of the 1906 quake,” said Schwartz. “It’s one thing to have a 1906-like earthquake where seismic activity is shut off, and we slide through the next 110 years in relative quiet. But what happens if every five years we get a magnitude 6.8 or 7.2? That’s not outside the realm of possibility.”
The paper, “The Earthquake Cycle in the San Francisco Bay Region: AD 1600-2012,” will be published online May 20, 2014 by BSSA and will appear in the June print issue. BSSA is published by the Seismological Society of America, which is an international scientific society devoted to the advancement of seismology and the understanding of earthquakes for the benefit of society.
“The Earthquake Cycle in the San Francisco Bay Region: AD 1600-2012,” published by BSSA. Authors: David Schwartz, USGS; James J. Lienkaemper, USGS; Suzanne Hecker, USGS; Keith I. Kelson, URS Corporation; Thomas E. Fumal, USGS; John N. Baldwin, Lettis Consultants International, Inc.; Gordon G. Seitz, California Geological Survey; Tina M. Niemi, University of Missouri-Kansas.
May 19, 2014
Imperial College London physicists have discovered how to create matter from light – a feat thought impossible when the idea was first theorised 80 years ago.
In just one day over several cups of coffee in a tiny office in Imperial’s Blackett Physics Laboratory, three physicists worked out a relatively simple way to physically prove a theory first devised by scientists Breit and Wheeler in 1934.
Breit and Wheeler suggested that it should be possible to turn light into matter by smashing together only two particles of light (photons), to create an electron and a positron – the simplest method of turning light into matter ever predicted. The calculation was found to be theoretically sound but Breit and Wheeler said that they never expected anybody to physically demonstrate their prediction. It has never been observed in the laboratory and past experiments to test it have required the addition of massive high-energy particles.
The new research, published in Nature Photonics, shows for the first time how Breit and Wheeler’s theory could be proven in practice. This ‘photon-photon collider’, which would convert light directly into matter using technology that is already available, would be a new type of high-energy physics experiment. This experiment would recreate a process that was important in the first 100 seconds of the universe and that is also seen in gamma ray bursts, which are the biggest explosions in the universe and one of physics’ greatest unsolved mysteries.
The scientists had been investigating unrelated problems in fusion energy when they realised what they were working on could be applied to the Breit-Wheeler theory. The breakthrough was achieved in collaboration with a fellow theoretical physicist from the Max Planck Institute for Nuclear Physics, who happened to be visiting Imperial.
Demonstrating the Breit-Wheeler theory would provide the final jigsaw piece of a physics puzzle which describes the simplest ways in which light and matter interact (see image in notes to editors). The six other pieces in that puzzle, including Dirac’s 1930 theory on the annihilation of electrons and positrons and Einstein’s 1905 theory on the photoelectric effect, are all associated with Nobel Prize-winning research (see image).
Professor Steve Rose from the Department of Physics at Imperial College London said: “Despite all physicists accepting the theory to be true, when Breit and Wheeler first proposed the theory, they said that they never expected it be shown in the laboratory. Today, nearly 80 years later, we prove them wrong. What was so surprising to us was the discovery of how we can create matter directly from light using the technology that we have today in the UK. As we are theorists we are now talking to others who can use our ideas to undertake this landmark experiment.”
The collider experiment that the scientists have proposed involves two key steps. First, the scientists would use an extremely powerful high-intensity laser to speed up electrons to just below the speed of light. They would then fire these electrons into a slab of gold to create a beam of photons a billion times more energetic than visible light.
The next stage of the experiment involves a tiny gold can called a hohlraum (German for ‘empty room’). Scientists would fire a high-energy laser at the inner surface of this gold can, to create a thermal radiation field, generating light similar to the light emitted by stars.
They would then direct the photon beam from the first stage of the experiment through the centre of the can, causing the photons from the two sources to collide and form electrons and positrons. It would then be possible to detect the formation of the electrons and positrons when they exited the can.
Lead researcher Oliver Pike who is currently completing his PhD in plasma physics, said: “Although the theory is conceptually simple, it has been very difficult to verify experimentally. We were able to develop the idea for the collider very quickly, but the experimental design we propose can be carried out with relative ease and with existing technology. Within a few hours of looking for applications of hohlraums outside their traditional role in fusion energy research, we were astonished to find they provided the perfect conditions for creating a photon collider. The race to carry out and complete the experiment is on!”
The research was funded by the Engineering and Physical Sciences Research Council (EPSRC), the John Adams Institute for Accelerator Science, and the Atomic Weapons Establishment (AWE), and was carried out in collaboration with Max-Planck-Institut für Kernphysik.
May 9, 2014
If you are sending Mother’s Day flowers to your mom this weekend, chances are you opted for guaranteed delivery: the promise that they will arrive by a certain time. Should the flowers not arrive in time, you will likely feel betrayed by the sender for breaking their promise. But if they arrive earlier, you likely will be no happier than if they arrive on time, according to new research. The new work suggests that we place such a high premium on keeping a promise that exceeding it confers little or no additional benefit.
Whether we make them with a person or company, promises are social contracts, says Ayelet Gneezy of the University of California, San Diego. While researchers have explored the negative consequences of breaking promises, until now, they have not explored what happens when someone exceeds a promise.
Gneezy became interested in the topic when thinking about how consumers respond to promises made by firms. “My first memory in that respect is that of Amazon’s tendency to exceed its promise with respect to delivery time – that is, packages always arrived earlier than promised – and my lack of appreciation of the ‘gesture’/fact,” Gneezy says.
Gneezy, with colleague Nicholas Epley of the University of Chicago Booth School of Business, set out to explore “promise exceeding” in a series of experiments that tested imagined, recalled, and actual promise-making. In one of the experiments, for example, researchers asked participants to recall three promises: one broken, one kept, and one exceeded. They then asked them to rate how happy they were with the promise-maker’s behavior.
While participants valued keeping a promise much more highly than breaking one, exceeding the promise conferred virtually no additional happiness with the promise-maker, as published today in Social Psychological and Personality Science. Additionally, in a follow-up experiment, participants said that exceeding a promise did not require expending significantly more effort.
In another experiment, researchers paired participants, making one the promise-maker and one the promise-receiver. The promise-receiver needed to solve 40 puzzles, being paid for each puzzle solved. The promise-maker promised to help in solving 10 puzzles. The experimenter then instructed the promise-makers to solve either the 10 puzzles (as promised), only 5, or 15.
Although exceeding the promise by solving 15 puzzles clearly required more effort, the promise- receivers did not value that extra work any more than just keeping to the 10 puzzles promised: They valued promise keeping and exceeding equally.
“I was surprised that exceeding a promise produced so little meaningful increase in gratitude or appreciation. I had anticipated a modest positive effect,” Epley says, but “what we actually found was almost no gain from exceeding a promise whatsoever.”
And the trend held true across the experiments: “Being able to demonstrate our effect so reliably across so many very different methods gives us great confidence in the robustness of these effects,” Epley says.
The data suggest that the reason for these effects lies in how we value promises as a society. “Keeping a promise is valued so highly, above and beyond its ‘objective’ value,” Epley says. “When you keep a promise, not only have you done something nice for someone but you’ve also fulfilled a social contract and shown that you’re a reliable and trustworthy person.”
The bottom line, Epley says, is that exceeding a promise may not be worth the effort you put in. “Invest efforts into keeping promises, not in exceeding them,” he says. And this advice also holds true for businesses, which should prioritize resources to make sure they do not break promises, rather than trying to go above and beyond.
To test this idea further, Epley and Gneezy asked participants in a follow-up study to imagine they had bought concert tickets for row 10 and then either received worse tickets than promised (row 11, 13, or 15), better tickets than promised (row 9, 7, or 5), or exactly what was promised. Participants were more negative about receiving worse tickets but were no more positive – nor more likely to recommend the company – when they received better tickets than promised.
Epley and colleague Nadav Klein are currently working on related work about how people evaluate selfless compared to selfish behavior and they are finding similar results. “Behaving fairly toward others is the critical point,” Epley explains. “Beyond being fair, generosity does not seem to be valued as much as one would expect.”
So, Epley says: “Don’t be upset when your friends, family members, clients, or students fail to appreciate the extra effort you put into going above and beyond your promise. They do not appear to be uniquely ungrateful, just human.”
May 6, 2014
The SETI project scientists are known for tracking possible extraterrestrial signals, but now they are also considering sending messages from Earth telling of our position. A researcher from the University of Cádiz (Spain) questions this idea in view of the results from a survey taken by students, revealing the general level of ignorance about the cosmos and the influence of religion when tackling these matters.
The Search for ExtraTerrestrial Intelligence (SETI) project is an initiative that began in the 70s with funding from NASA, but that has evolved towards the collaboration of millions of Internet users for the processing of data from the Arecibo Observatory (Puerto Rico), where space tracking is carried out.
Now the members of this controversial project are trying to go further and not only search for extraterrestrial signs, but also actively send messages from Earth (Active SETI) to detect possible extraterrestrial civilisations. Astrophysicists, such as Stephen Hawking, have already warned of the risk that this implies for humanity, since it could favour the arrival of beings with more advanced technology and dubious intentions.
The ethical and sociological implications of this proposal have been analysed by the neuro-psychologist Gabriel G. de la Torre, professor at the University of Cádiz and participant in previous projects such as Mars 500 or space psychology topical team project financed by the European Space Agency, who wonders: “Can such a decision be taken on behalf of the whole planet? What would happen if it was successful and ‘someone’ received our signal? Are we prepared for this type of contact?”
To answer these questions, the professor sent a questionnaire to 116 American, Italian and Spanish university students. The survey assessed their knowledge of astronomy, their level of perception of the physical environment, their opinion on the place that things occupy in the cosmos, as well as religious questions – for example, “do you believe that God created the universe?” – or on the likelihood of contact with extraterrestrials.
The results, published in the journal ‘Acta Astronautica‘, indicate that, as a species, humanity is still not ready for trying to actively contact a supposed extraterrestrial civilisation, since people lack knowledge and preparation. For this reason, SETI researchers are recommended in this study to look for alternative strategies.
“This pilot study demonstrates that the knowledge of the general public of a certain education level about the cosmos and our place within it is still poor. Therefore, a cosmic awareness must be further promoted – where our mind is increasingly conscious of the global reality that surrounds us – using the best tool available to us: education,” De la Torre emphasised. “In this respect, we need a new Galileo to lead this journey”.
It was deduced from the questionnaires, which will soon be available to everyone on line, that university students and the rest of society lack awareness on many astronomical aspects, despite the enormous progress of science and technology. It also revealed that the majority of people consider these subjects according to their religious belief and that they would rely on politicians in the event of a huge global-scale crisis having to be resolved.
“Regarding our relation with a possible intelligent extraterrestrial life, we should not rely on moral reference points of thought, since they are heavily influenced by religion. Why should some more intelligent beings be ‘good’?,” added the researcher, who believes that this matter should not be monopolized by a handful of scientists: “In fact, it is a global matter with a strong ethical component in which we must all participate”.
Gabriel G. De la Torre. “Toward a new cosmic consciousness: Psychoeducational aspects of contact with extraterrestrial civilizations”. Acta Astronautica 94 (2): 577 – 583, 2014.
May 5, 2014
Harvard Stem Cell Institute (HSCI) researchers have shown that a protein they previously demonstrated can make the failing hearts in aging mice appear more like those of young health mice, similarly improves brain and skeletal muscle function in aging mice.
In two separate papers given early online release today by the journal Science - which is publishing the papers this coming Friday, Professors Amy Wagers and Lee Rubin, of Harvard’s Department of Stem Cell and Regenerative Biology (HSCRB), report that injections of a protein known as GDF11, which is found in humans as well as mice, improved the exercise capability of mice equivalent in age to that of about a 70-year-old human, and also improved the function of the olfactory region of the brains of the older mice – they could detect smell as younger mice do.
Rubin and Wagers each said that, baring unexpected developments, they expect to have GDF11 in initial human clinical trials within three to five years. Postdoctoral fellow Lida Katsimpardi is the lead author on the Rubin group’s paper, and postdocs Manisha Sinha and Young Jang are the lead authors on the paper from the Wagers group.
Both studies examined the effect of GDF11 in two ways. First, by using what is called a parabiotic system, in which two mice are surgically joined and the blood of the younger mouse circulates through the older mouse. And second, by injecting the older mice with GDF11, which in an earlier study by Wagers and Richard Lee, of Brigham and Women’s Hospital who is also an author on the two papers released today, was shown to be sufficient to reverse characteristics of aging in the heart.
Doug Melton, co-chair of HSCRB and co-director of HSCI, reacted to the two papers by saying that he couldn’t “recall a more exciting finding to come from stem cell science and clever experiments. This should give us all hope for a healthier future. We all wonder why we were stronger and mentally more agile when young, and these two unusually exciting papers actually point to a possible answer: the higher levels of the protein GDF11 we have when young. There seems to be little question that, at least in animals, GDF11 has an amazing capacity to restore aging muscle and brain function,” he said.
Melton, Harvard’s Xander University Professor continued, saying that the ongoing collaboration between Wagers, a stem cell biologist whose focus has been on muscle, Rubin, whose focus is on neurodegenerative diseases and using patient generated stem cells as targets for drug discover, and Lee, a practicing cardiologist and researcher, “is a perfect example of the power of the Harvard Stem Cell Institute as an engine of truly collaborative efforts and discovery, bringing together people with big, unique ideas and expertise in different biological areas.”
As Melton noted, GDF11 is naturally found in much higher concentration in young mice than in older mice, and raising its levels in the older mice has improved the function of every organ system thus far studied.
Wagers first began using the parabiotic system in mice 14 years ago as a post doctoral fellow at Stanford University, when she and colleagues Thomas Rando, of Stanford, Irina Conboy, of UC Berkley, and Irving Weissman, of Stanford, observed that the blood of young mice circulating in old mice seemed to have some rejuvenating effects on muscle repair after injury.
Last year she and Richard Lee published a paper in which they reported that when exposed to the blood of young mice, the enlarged, weakened hearts of older mice returned to a more youthful size, and their function improved. And then working with a Colorado firm, the pair reported that GDF11 was the factor in the blood apparently responsible for the rejuvenating effect. That finding has raised hopes that GDF11 may prove, in some form, to be a possible treatment for diastolic heart failure, a fatal condition in the elderly that now is irreversible, and fatal.
“From the previous work it could have seemed that GD11 was heart specific,” said Wagers, “but this shows that it is active in multiple organs and cell types Prior studies of skeletal muscle and the parabiotic effect really focused on regenerative biology. Muscle was damaged and assayed on how well it could recover,” Wagers explained.
She continued: “The additional piece is that while prior studies of young blood factors have shown that we achieve restoration of muscle stem cell function and they repair the muscle better, in this study, we also saw repair of DNA damage associated with aging, and we got it in association with recovery of function, and we saw improvements in unmanipulated muscle. Based on other studies, we think that the accumulation DNA damage in muscle stem cells might be reflect an inability of the cells to properly differentiate to make mature muscle cells, which is needed for adequate muscle repair.
Wagers noted that there is still a great deal to be learned about the mechanics of aging in muscle, and its repair. “I don’t think we fully understand how this happening or why. We might say that the damage is modification to the genetic material; the genome does have breaks in it. But whether it’s damaging, or a necessary part of repair, we don’t know yet.”
Rubin, whose primary research focus is on developing treatment for neurodegenerative diseases, particularly in children, said that that when his group began its GDF11 experiments, “we knew that in the old mouse things were bad in the brain, there is a reduced amount of neurogenesis (the development of neurons), and it’s well known that cognition goes down. It wasn’t obvious to me that those things that can be repaired in peripheral tissue could be fixed in the brain.”
Rubin said that post doctoral fellow Lida Katsimpardi, the lead author on his group’s paper, was taught the parabiotic experimental technique by Wagers, but conducted the Rubin group’s experiments independently of the Wagers group, and “she saw an increase in neural stem cells, and saw increased development of blood vessels in the brain.” Rubin said that 3D reconstruction of the brain, and magnetic resonance imaging (MRI) of the mouse brain showed “more new blood vessels and more blood flow,” both of which are normally associated with younger, healthier brain tissue.” Younger mice, Rubin said, “have a keen sense of olfactory discrimination,” they can sense fine differences in odor. “When we tested the young mice, they avoided the smell of mint; the old mice didn’t. But the old mice exposed to the blood of the young mice, and those treated with GDF11 did.
“We think an effect of GDF 11 is the improved vascularity and blood flow, associated with increased neurogenesis,” Rubin said. “This should have other more widespread effect on other areas of the brain. We do think that, at least in principal, there will be a way to reverse some of the decline of aging with a single protein. It could be that a molecule like GDF 11, or GDF 11 itself, could” reverse the damage of aging.
“It isn’t out of question that GDF11,” or a drug developed from it, “might be worthwhile in Alzheimer’s Disease,” Rubin said. “You might be able to separate out the issues of treating the plaque and tangles associated with the disease, and the decline in cognition, and perhaps improve cognition.” Wagers said that the two research groups are in discussions with a venture capital group to obtain funding to “be able to do the additional pre-clinical work” necessary before moving GDF 11 into human trials.
“I would wager that the results of this work, together with the other work, will translate into a clinical trial and a treatment,” said the stem cell biologist. “but of course that’s just a wager.”
“We think an effect of GDF 11 is the improved vascularity and blood flow, which is associated with increased neurogenesis,” Rubin said. “However, the increased blood flow should have more widespread effects on brain function. We do think that, at least in principle, there will be a way to reverse some of the cognitive decline that takes place during aging, perhaps even with a single protein. It could be that a molecule like GDF 11, or GDF 11 itself, could” reverse the damage of aging.
“It isn’t out of question that GDF11,” or a drug developed from it, “might be capable of slowing some of the cognitive defects associated with Alzheimer’s Disease, a disorder whose main risk factor is aging itself,” Rubin said. It is even possible that this could occur without directly changing the “plaque and tangle burden” that are the pathological hallmarks of Alzheimer’s. Thus, a future treatment for this disease might be a combination of a therapeutic that reduces plaques and tangles, such as an antibody directed against the β-amyloid peptide, with a potential cognition enhancer like GDF-11.
Wagers said that the two research groups are in discussions with a venture capital group to obtain funding to “be able to do the additional preclinical work” necessary before moving GDF 11 into human trials.
“I would wager that the results of this work, together with the other work, will translate into a clinical trial and a treatment,” said the stem cell biologist. “but of course that’s just a wager.”