New Colon Cancer Vaccine: Clinical Trials Show Promise

March 19, 2009

(ChattahBox)—Clinical trials for a promising new colon cancer vaccine are currently underway at the University of Pittsburgh School of Medicine and due soon to enroll another 50 patients. Principal investigator Robert E. Schoen, M.D, believes the vaccine can be effective in preventing colon cancer in patients with an increased risk for developing polyps and cancerous adenomas, and/or who have a family history of the disease. Additionally, patients using the vaccine can probably forego the need for repeated colonoscopies, used to discover and remove polyps. This new vaccine is great news for the estimated 108,000 patients who develop colon cancer every year.

The vaccine targets a self-made cell protein called MUC1, which is produced in patients with advanced cancerous adenomas. The unique vaccine works to stimulate an immune response to fight against the MUC1 protein, which in turn destroys the abnormal cells. Current cancer vaccines, work quite differently; they block infection from viruses associated with cancer. The MUC1 vaccine may not only stop polyps from turning cancerous, but may also stop the formation of polyps all together.

At the completion of the first stage of a small-scale clinical trial of 12 participants, researchers reported that the patients developed an immune response when treated with the vaccine. The trial patients all had late-stage colon cancer and pancreatic cancer. The next trial will treat 50 people with the vaccine who are healthier and researchers expect results that are even more promising.

The Pittsburgh School of Medicine is currently enrolling people between 40 and 70 years old with a history of advanced adenomas. Researchers define advanced adenomas as those greater than or equal to 1 centimeter in size, are typed as villous or tubulovillous, or contain severely dysplastic, or abnormal, cells. Trial participants will receive an initial dose of the vaccine, with additional doses at two and 10 weeks later.


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  1. Lance Armstrong Foundation Announces Human Rights Leader and Former - PR Inside on March 19th, 2009 5:20 pm

    […] New Colon Cancer Vaccine: Clinical Trials Show Promise – Chattahbox.com( ChattahBox) Clinical trials for a promising new colon cancer vaccine are currently underway at the University of Pittsburgh School of Medicine and due soon to enroll another 50 patients. Principal investigator Robert E. Schoen, M.D, believes the Filed under Cancer Research by admin Permalink • Print • Email […]

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