New Muscular Dystrophy Drug Shows Promise

June 19, 2009

(ChattahBox)— A new drug may offer hope to children with Bethlem Myopathy and Ullrich Congenital Muscular Dystrophy, a devastating genetic muscle wasting disease with no cure. The drug could replace current drugs, without causing dangerous immune suppressant side effects.

A team of researchers from the University of Padova in Italy conducted a study on mice of a new drug, called Debio 025 that shows great potential for slowing the progression of the muscle wasting disease. More importantly, the drug didn’t suppress the immune systems of the mice, making it suitable for long-term use.

After just five days on Debio 025, the researchers found decreases in the numbers of abnormal muscle fibres in the treated mice.

The only current drug used to treat Myopathy and Ullrich Congenital Muscular Dystrophy, is cyclosporin, but isn’t safe for long-term use because of its immune suppressant properties and its interaction with the protein, calcineurin.

Debio 025 had the same results on the mice as cyclosporin, but without the dangerous side effects. The researchers plan to conduct further studies and are confident that this new drug could someday replace cyclosporin, which would slow or stop the progression of the muscle wasting.

The study is available in the British Journal of Pharmacology.

Source


Comments

2 Responses to “New Muscular Dystrophy Drug Shows Promise”

  1. New Muscular Dystrophy Drug Shows Promise Adding Info on June 19th, 2009 1:00 pm

    […] team of researchers from the University of Padova in Italy conducted … Read Full Post: New Muscular Dystrophy Drug Shows Promise Adding Related Info:Progress Made Toward Early Identification Of Muscular Dystrophy – Science […]

  2. Ali on January 23rd, 2010 4:40 pm

    You can find more information on Muscular Dystrophy in:
    http://www.geneticsofpregnancy.com/Encyclopedia/Muscle_diseases_and_muscular_dystrophy.aspx?pid=62
    This site contains information On Pregnancy Diseases And Genetic Testing.

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