New Urine Test to Detect Appendicitis in Children, Shows Promise

June 23, 2009

(ChattahBox)—Researchers from the Proteomics Center at Children’s Hospital, Boston have developed a breakthrough urine test, which detects “biomarkers” indicating appendicitis in children. This new test should improve diagnosis and replace CT scans that expose children to radiation.

Appendicitis is often difficult to detect accurately in children, resulting in unnecessary surgeries or the prospect of a serious ruptured appendix, before a diagnosis is made. Researchers from Boston Children’s Hospital evaluated urine samples, using a proteomics study with the aid of state-of-the art mass spectrometry.

The researchers, using these advanced methods were able to detect several biomarkers, including proteins associated with immune response and inflammation.

The researchers evaluated urine samples taken from children before and after an appendectomy and were able to narrow down the biomarkers to one that showed the most sensitivity to testing. The winning biomarker was leucine-rich alpha-2-glycoprotein, or LRG, which showed a near perfect sensitivity value of 0.97, with almost no false positives or negatives.

Next, researchers plan to develop a quick and inexpensive method to detect the biomarker, such as a urine dipstick.

The advanced field of proteomics should play a major role in discovering diagnostic markers for other pediatric diseases, providing early diagnosis and saving lives.

This groundbreaking study is available online in the latest issue of the Annals of Emergency Medicine.

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One Response to “New Urine Test to Detect Appendicitis in Children, Shows Promise”

  1. New Urine Test to Detect Appendicitis in Children, Shows Promise Adding Info on June 23rd, 2009 10:37 am

    […] is often difficult to detect accurately in children, resulting in unnecessary surgeries or … Read Full Post: New Urine Test to Detect Appendicitis in Children, Shows Promise Adding Related Info:New Muscular Dystrophy Drug Shows PromiseX-Ray May Detect Alzheimer’s Disease […]

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