Reliable early detection test for Alzheimer’s Disease verified

March 17, 2009

(ChattahBox) — Scientists have been seeking ways to diagnose Alzheimer’s in its early stages, and now it seems to be a reality. The University of Pennsylvania School of Researchers announced on Monday that a new test can accurately detect or rule out Alzheimer’s disease in its earliest stages.

The test, measures proteins in cerebrospinal fluid (CSF), specifiaclly concentrations of two of the disease’s biochemical hallmarks – amyloid beta42 peptide and tau protein, which can point to Alzheimer’s with 87 percent accuracy for patients with early memory problems. The team evaluated spinal fluid taken from 410 patients who were part of a large Alzheimer’s study and positively predicted the conversion from mild cognitive impairment to Alzheimer’s disease at a rate of 81.8 percent.  It also ruled out the disease in 95.2 percent of the volunteers.  Dr.Leslie Shaw who lead a team at the University of Pennsylvania School of Medicine says:

“With this test, we can reliably detect and track the progression of Alzheimer’s disease. Validated biomarker tests will improve the focus of Alzheimer’s clinical trials, enrolling patients at earlier stages of the disease to find treatments that can at least delay –and perhaps stop– neurodegeneration. In addition, prevention trials can test methods to delay or block mild cognitive impairment from converting to full-blown Alzheimer’s.”

It’s hoped that early detection will lead to better strategies to keep mild memory impairments from progressing into full-blown Alzheimer’s disease, a fatal, mind-robbing ailment that is the most common form of dementia in the elderly, he added.

Complete details of the findings can be found on the Penn Medicine Website here.


One Response to “Reliable early detection test for Alzheimer’s Disease verified”

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