New Cancer Drug Successful With Dogs: Human Trials are Next

March 25, 2009

(ChattahBox)—A group of researchers from The Cleveland Clinic, led by Joseph A. Bauer, Ph.D, presented their successful results of the use of the drug nitrosylcobalamin or (NO-Cbl), in treating cancerous tumors in dogs. The promising study was presented this week in Salt Lake City, during the American Chemical Society’s National Meeting. The researchers gave the drug, to three dogs suffering from advanced cancer, with the tumors in all the dogs showing a remarkable reduction in size. Researchers say that clinical success in dogs makes it even more likely the drug will work on humans.

The experimental drug nitrosylcobalamin is a compound of the vitamin B12, which acts as a delivery system for nitric oxide that has shown to have potent antitumor qualities. The researchers used the new drug on three dogs: a 13-year-old female Giant Schnauzer with a thyroid carcinoma, a 6-year-old male Golden Retriever with a malignant peripheral nerve sheath tumor, and a 10-year-old male Bichon Frise with anal sac adenocarcinoma. The dogs were administered a 28 mg/kg dose of the drug two times per day.

The results were amazing. The Giant Schnauzer showed a 77 percent reduction in the size of her tumor after 10 months of treatment, with the Golden Retriever showing a 39 percent reduction in his tumor size after nine months. The Bichon Frise, named Oscar, referred to as the “miracle dog,” is a real success story.

The very ill Oscar arrived on the researcher’s doorstep, after receiving doses of chemotherapy and radiation that were ineffective, no longer able to walk and expected to die within two weeks. After 15 months of treatment with (NO-Cbl), Oscar had a 43 percent reduction of his deadly tumor and an amazing 90 percent reduction of his lymph node tumor. Oscar is now able to walk again, and his prognosis looks promising for his return to digging up holes in his backyard and happily retrieving Frisbees.

The Cleveland Clinic researchers plan to start clinical trials on humans in the very near future.



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