Research identifies organism that could trigger colic

July 25, 2009

ChattahBox) — Researchers at The University of Texas Health Science Center at Houston say their study may unlock the key to what causes colic, i.e. the inconsolable crying in an otherwise healthy baby. Painful gas may contribute to colic, but doctors have not necessarily linked the condition to digestive problems.

Published in the July 23 online edition of the Journal of Pediatrics, the study pointed to an organism called Klebsiella, a normally occurring bacterium that can be found in the mouth, skin and intestines. In the study of 36 babies, half of which had colic, researchers found the bacterium and gut inflammation in the intestines of the babies with colic.

“We believe that the bacterium may be sparking an inflammatory reaction, causing the gut inflammation,” said Rhoads, the lead investigator for the study. “Inflammation in the gut of colicky infants closely compared to levels in patients with inflammatory bowel disease. Colic could prove to be a precursor to other gastrointestinal conditions such as irritable bowel syndrome, celiac disease and allergic gastroenteropathies.”

Colic usually occurs in infants three months old or younger and lasts for more than three hours daily for at least three days a week. “Colic is a very common condition. It affects about 15 percent of normal, healthy infants. More than half of infanticides fall into the age category of colic. We may be able to prevent deaths if we can find a treatment,” Rhoads said.

Right now, pediatricians prescribe special hypoallergenic infant formula to try and treat colic, but none of it has been proven in studies to be effective in treating the condition.

“During our study, we also found that the babies that didn’t have colic had more types of bacteria in their intestines. The presence of more bacteria may indicate that specific bacterial species (phylotypes) are beneficial to humans,” Rhoads said.

The study was funded by the Gerber Foundation.

A larger study is needed to examine Klebsiella and the use of a probiotic, which is a dietary supplement made up of good bacteria, to control the gut inflammation. Before that can begin, Rhoads said an adult trial will take place to examine the safety of the probiotics in healthy adults. For that study, UT researchers are recruiting 40 adult patients.

Other research personnel at the UT Medical School included Nicole Fatheree, research coordinator; Yuying Liu, Ph.D., researcher; Joseph Lucke, Ph.D. and Jon E. Tyson, M.D., professor of pediatrics and obstetrics and Michelle Bain Distinguished Professor in Medicine and Public Health.

On a personal note I suffered a form of IBD for years and found doctors including gastroenterologists, totally clueless about the relationship of these diseases and gut bacteria balance. The right probiotic and it’s not the same one for everyone can make a huge difference.

Source: The University of Texas Health Science Center at Houston


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