Blood pressure medication successfully treats multiple sclerosis in animal model

August 18, 2009

(ChattahBox) — Dr. Michael Platten, head consultant at the department of Neurooncology at University Hospital Heidelberg and head of the Helmholtz Experimental Neuroimmunology Junior Research Group on at the German Cancer Research Center and his team in cooperation with scientists from Stanford University in California have made a discovery that could be a breakthrough for multiple sclerosis (MS).  A conventional blood pressure medication called ACE inhibitors and AT1R blockers can suppress inflammation in mice suffering from an autoimmune disease comparable to MS.

Inflammation and paralysis reversed

In their tests, the Heidelberg researchers first showed that the RAAS was actually elevated in MS foci in the brains of deceased MS patients. They then treated mice that had an autoimmune disease of the nervous system similar to MS with ACE inhibitors and AT1R blockers. The results were astonishing – the drugs suppressed specific immune cells that were instrumental in promoting inflammation. In addition, they increased anti-inflammatory immune cells that reversed existing neuroinflammation and subsequent paralysis.

Clinical studies to follow soon

Since the animal model the researches employed is an established model that is frequently used for drug development in MS, the researchers hope that the results are transferable to humans. Clinical trials analyzing the efficacy of ACE inhibitors in MS patients are currently being planned. “The use of this blood pressure medication is an attractive strategy for treating autoimmune diseases. The drugs are already used by millions of people, are cheap, and have few side effects,” explains Professor Lawrence Steinman, partner of the Heidelberg researchers at Stanford University.

The results are published in the Proceedings of the National Academy of Sciences (PNAS) back-to-back with a report of a Bochum team that also supports the new role for ACE inhibitors.

Via: BreakThroughDigest Medical News


Comments

2 Responses to “Blood pressure medication successfully treats multiple sclerosis in animal model”

  1. David on August 19th, 2009 9:32 am

    This is absurd and I hope no one pays attention to it. Tests done on animals have been proven over and over again to be innacurate due to the fact that the biology of mice and other animals is just much to different.

    WE HAVE BEEN CURING CANCER IN RATS FOR YEARS, PEOPLE!

    get a clue

  2. nutrition on September 29th, 2009 5:08 am

    This is really wonderful article. I come to know this things which I didn’t know before. Thank you for this. I will use this information in my final project also.

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